Jay Prakash Sah, Chandra Kant Yadav and Dipendra Kumar yadav
High-sensitivity C-reactive protein (hs-CRP) is an acute phase protein produced as a marker of inflammation. It may play role as predictor of inflammation in patients with type 2 diabetes. The aim of this study was to estimate blood hs-CRP and urea level and also to determine association between them. The relationship between inflammation and blood urea level in type- 2 diabetes mellitus has not yet been reported in Nepalese population. So a quantitative laboratory based, descriptive, analytical study were done by enrolling 89 type 2 diabetic patients conducted at Tertiary Care Hospital. We analyzed serum concentrations of high sensitive C-reactive protein (hs-CRP), urea, blood glucose and family history of the patients. In our study, we found the significant association between serum hs-CRP and Serum Urea level (P values<0.01).We also found a significant association between serum hs-CRP and Blood Glucose level (P values=0.01). Furthermore, serum hs-CRP was not correlated with both family history of patients (P >0.197) and sex( P>0.265). This study concludes that the increase in serum hs-CRP value in type 2 diabetic patients increases the risk of diabetic nephropathy and thus increase the value of serum urea level. And there is no correlation of serum hs-CRP and urea level with the risk factors especially sex and family history of type 2 diabetes. The significance of these findings is a new diagnostic tool for early screening of diabetic nephropathy in type 2 diabetic patients to prevent from further complication.
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