Journal américain de l'administration de médicaments et de la thérapeutique Libre accès

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Anti-inflammatory and Diuretic Activities of Ethanol Extract of Dioscorea bulbifera Leaf

Omodamiro OD

Objective: The present study was designed to determine the antiinflammatory and diuretic activities of the plant Dioscorea bulbifera. In the anti-inflammatory study, thirty two animals were used and they were randomly distributed four animals per group. Method: Administered concentration of Dioscorea bulbifera were 500mg/kg, 250mg/kg, 125mg/kg, 62.5mg/kg and 31.25mg/kg, 15.5mg/kg were given to the test group labeled group A to F. A negative control receiving normal saline at 0.9mg/kg and a positive control receiving aspirin at 100mg/kg were as control groups for the study. Egg albumin was used as the inflammatory agent. Result: The negative control showed no inhibition. Further results showed that the concentration at 500mg/kg of the ethanol extract had the highest anti-inflammatory effect at 20.4 ± 0.14. In the diuretic study, the negative control containing the normal saline and the positive control containing furosemide were used. The albino rats were administered the extracts at conc. at 1000mg/ml, 500mg/ml, 250mg/ml, 62.5mg/ml and 31.25mg/ml. the albino rats administered the positive control had the highest volume of urine but were low in Na+ /K+ at 25.79 ± 1.124. Conclusion: This result demonstrates that Dioscorea bulbifera has potential anti-inflammatory effects and little diuretic activities.