Journal américain de l'administration avancée de médicaments Libre accès

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Synthesis and Antimicrobial Activity of Some New 5-Oxo-Imidazolidine Derivatives

Vivek Gupta1, A. Pandurangan

Schiff bases are synthesized from paracetamol. 4-acetamidophenoxyacetylhydrazide is synthesized from paracetamol, which on reaction with various aldehydes gives Schiff bases. Schiff bases treated with amino-acetic acid to produce Imidazolidine derivatives. The entire synthesized compound characterized by physical and analytical data. The chemical structures of synthesized compound were confirmed by means of IR, 1HNMR and MS. Antimicrobial activity of synthesized compounds evaluated by cup-plate method. Synthesized compound showed good antimicrobial activity.