Assist Prof Dr. Karunrat Tewthanom
The trend in Pharmacogenomic knowledges has been widely popular and use in many fields, including oncology. The literature review found that there are many studies about the useful of pharmacogenomic monitoring in patients with cancer, both for therapeutics and adverse effect monitoring. An example of Pharmacogenomics in therapeutics monitoring is breast cancer, the HER 2 positive patients will be have more chance to achieve goal of therapy. In safety monitoring circumstance for example in chronic myeloid leukemia who receive tyrosine kinase inhibitor, with should be screen for UGT1A1 polymorphism because it impacts on adverse events for nilotinib.
Conclusion & Significance: From the literature review implies that pharmacogenetic monitoring has more important in oncology. It is useful for both therapeutic and safety monitoring
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