Abdulkadir Yusif Maigoro*, Syeda Hafiza Benish Ali
Interleukin 17-A (IL17A) is one of the major cytokines known to play a role in different pathologies, including Autoim- mune Diseases (AIDs). IL17A gene has different Single Nucleotide Polymorphisms (SNPs); rs2275913 being frequent- ly studied SNP with susceptibility to autoimmune diseases. However, the results for this SNP have remained incon- clusive. Therefore, in this meta-analysis we gathered data from different studies conducted in different populations (Europe, Asia, New Zealand, Africa and Latin America) to find out the role of rs2275913 in overall susceptibility of AIDs. After thorough search and careful screening, a total of 5424 cases and 7221 controls were cumulatively found in 16 eligible studies from 13 different research papers. Analyses were done under co-dominant homozygous (AA vs. GG), co-dominant heterozygous (GA vs. GG), dominant (AA+GA vs. GG), recessive (AA vs. GG+GA) and allelic (A vs. G) models. All the eligible studies were in line with Hardy-Weinberg equilibrium and the I2 values of all models were <50%. Significant Q values were found only for the dominant (p=0.09) and allelic (p=0.07) models. No publication bias was seen when funnel plots were constructed. Significant protective effect of an allele (OR<1, p<0.05) was ob- served in some individual studies on rheumatoid arthritis and periodontitis. However, the results of meta-analysis in total fixed effect and total random effect of all the studies in different models showed no significant association. As per the best of our knowledge, this is the first report of meta-analysis of rs2275913 of IL17A gene with respect to autoimmune diseases susceptibility.
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