Revue de biochimie et de biologie moléculaire Libre accès

Abstrait

Prevalence of Metabolic Syndrome in Hemodialysis Patients Follow-Up for Three Years: Relationship with Cardiovascular Disease Development

Ben Omrane Sioud Olfa, El-Ati Zohra, Machfar Hanen, Knani Ines, Bouzidi Hassan, Kerkeni Mohsen and Hammami Mohamed

Background: Cardiovascular complications were the major cause of morbidity and mortality in hemodialysis patients (HD). It was closely related with metabolic syndrome (MS) in general population. This study aimed to determine prevalence of MS in HD patients and to evaluate the relationship between the prevalence of MS and the presence of cardiovascular disease (CVD) in HD patients through three years later.

Methods: A total of two hundreds participants were included in this study, 100 patients receiving regular hemodialysis and 100 healthy controls. Clinical data, lipid profile and atherogenic indices (cholesterol/HDL, triglycerides/HDL) were measured.

Results: Prevalence of MS in HD patients was 46%. Cardiovascular diseases present 43%. We found statistic significant difference between level of lipid profile and atherogenic index between the two groups of participants. For patients with MS and with CVD, a significant increased level was found between cholesterol (TC), triglycerides (TG) and atherogenic index after three years. For three year follow-up, patients with MS have an increased prevalence for CVD compared to patients without MS.

Conclusion: For three years follow-up, the lipid profile and atherogenic index in HD patients were increased with presence of MS and HD patients with MS have showed an increased CVD risk.