Mariana Luna
“Metabolic Indicating that programming” intrauterine Growing body of evidence supports the essential to offspring health in subsequent life stages. Adverse situations during this period of life, like maternal overweight or poor maternal diet, can influence neuroendocrine and energetic balance from the fetus through lifelong time1-7. Thus, impacts of maternal nutritional status on cardiovascular risk parameters in adolescent offspring have been increasingly observed1-3,8,9. However, recent studies, mainly in animals, have been indicating that pregnancy can affect the developing fetus in different ways, depending on sex, where boys would be more affected than girls 10-16. Methods This is a cross-sectional study with 49 adolescents, performed in an Adolescent Health Center in state of Rio de Janeiro, Brazil. Adolescent variables were collected in a scheduled visit, when sociodemographic (sex and age), clinical (diastolic and systolic blood pressure), anthropometric (weight, height, BMI and waist circumference [WC]), biochemical (glucose, total cholesterol, LDL-c, HDL-c, triglycerides and leptin) and at birth (birth weight and gestational age) variables were evaluated. Conclusion Based on the results from this study, maternal anthropometric variables were correlated with anthropometric and biochemical variables in boys, in a moderate to very-strong way. Hence, for girls, the only correlations observed were in relation to leptin, and in a weak degree. It suggests that maternal nutritional status may influence adiposity, its Methylation of DNA during critical periods of development can occur.
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