Journal américain de l'administration avancée de médicaments Libre accès

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In Vivo-In Vitro Evaluation of Solid Dispersion Containing Ibuprofen

Sachin K. Gawai, Subhash V. Deshmane, R. N. Purohit, Kailash R. Biyani

Ibuprofen is a non-steroidal anti-inflammatory drug with poor water solubility. The most frequent causes of low oral bioavailability are attributed to poor solubility and low permeability. Solid dispersion technique can be used to enhance the solubility; dissolution rate and absorption of several insoluble drugs. The different solid dispersion methods were studied using PEG 6000 as carrier. Different ratio of drug-carrier was study. The all samples were characterized by FTIR study. Tests of physical evaluation, drug content, loss drying and invitro dissolution were carried out. The formulation of 1:2 ratio by fusion method was found optimized. In-vivo anti-inflammatory activity of 1:2 ratio formulation of fusion method shows highest dissolution and absorption rate than marketed preparation. The present study concluded with the importance of solid dispersion technique and their methods in enhancing the solubility of poorly water soluble drug.