Journal de pharmacie et de recherche pharmaceutique Libre accès

Abstrait

Group 15 Organotin Containing Polyamines from Histamine and Their Ability to Inhibit Cancer Cell Lines from Pancreatic, Breast and other Cancers

Charles E. Carraher Jr., Michael R. Roner, Zamil Islam and Alisia Moric-Johnson

The Polyamines of GroupVA are synthesized under low yield moderate to high molecular weight employing the commercially available reactants and the interfacial polycondensation system. The IR spectroscopy determines the formation of bands characteristic to M-N bonds. Whereas MALDI MS determines the ion fragments to three units long with isotopic abundance results showing antimony in the triphenylantimony-derived clusters.

The absence of the histamine ring proton in Nuclear magnetic resonance is constraint forming polyamine structure. Tumor analyzes the polymers inhibiting growth of cancer cell line with the triphenylarsenic/histamine polymer exhibiting outstanding ability for the inhibition of PANC-1 pancreatic cell line with the best CI₅₀ values thus far found.