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Environmental Exposures Lead to Premature Age-Related Diseases

Ziyi Yang

The Age-related diseases are diseases that occur with increasing frequency as aging increases. It covers many kinds of diseases which mostly happen in the elderly, such as the atherosclerosis, arthritis, osteoporosis, type-2 diabetes, stroke, chronic kidney disease, and cardiovascular disease. This paper aims to identify the relationship between the heavy metals and pesticide in blood and urine with age-related diseases. For arthritis, cardiovascular disease, stroke, chronic kidney disease, macular disease and atherosclerosis, the National Health and Nutrition Examination Survey (NHANES) can directly determine who has these specific diseases. However, for Alzheimer’s and Parkinson’s, these two diseases could not be directly seen through a single variable. The respondents who have these two diseases could be justified by other variables. For example, Alzheimer’s could be defined based on the cognitive function datasets, and Parkinson’s could also be defined by the prescription medicine datasets in the NHANES. The metals in blood and urine have been selected in 18 different kinds of metals, and the pesticide content in blood and urine have also been included in the NHANES. By calculating the P-value between the diseases and the heavy metals, it demonstrates that the concentrations of cadmium, mercury and many of the heavy metals are associated with many age-related diseases, not only one disease.

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