O. E. Yakubu, E. Ojogbane, O. F. C. Nwodo, V. O. Nwaneri-Chidozie and K. Dasofunjo
Diabetes was induced intraperitoneally using 50mg/kg streptozotocin, while diabetic rats were treated with 100mg/kg ethanol extract and glibenclamide (2.5mg/kg) respectively for 28 days. Normal rats received distilled water. Changes in fasting blood sugar (FBS) serum creatinine and urea levels thiobarbituric acid reactive substances (TBARS) in the kidney as well as kidney catalase (CAT) and superoxide dismutase (SOD) activities were assayed. The results revealed that the FBS, TBARS, creatinine and urea levels were increased while SOD and CAT activities decreased significantly (P<0.05) in control rats. Treatment with extract was able to revert these parameters to normal by increasing SOD and CAT and decreasing FBS, TBARS, urea and creatinine. Extract treatment demonstrated more effect compared to glibenclamide treatment. However, the extract was able to manage hyperglycaemia and diabetes -induced oxidative changes in the kidney, thus suggesting its use for the management of diabetes and its complications affecting the kidney.
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