Journal américain de l'administration avancée de médicaments Libre accès

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Effect of Multi Drug Administration on Cardiac Enzymes and Tissues

Afshan Siddiq and Rafeeq Alam Khan

In the present study individual and combinations of drugs were given to rabbits for the period of 60 days and their effects on cardiac function and myocytes were observed. Results shows that as compared to control rabbits, administration of acarbose, glibenclamide individually and GLoAt combination showed highly significant increase (p <0.005) in CK. The animals received Losartan individually showed highly significant decrease (p <0.005) in CK. Animal received Atorvastatin showed significant decrease in CK (p <0.05) while animal received MAAt combination showed significant increase in CK (p <0.05). Similarly with respect to control, animals received Metformin showed significant increase (p <0.05) in GOT level and highly significant increase (p <0.005) in animals received combination GLoAt