Jinan Hussein Murtadha* and Iman Hashim Abdul-Razzaq
Beta-thalassemia is a category of hemoglobin synthesis disorders that are recessively autosomal. The most important cause of mortality and morbidity is these patients with thalassemic is organ failure related with shortened red cell life span, rapid iron turnover and tissue deposition of excess iron. The present study was carried out on a total of 50 thalassemic patients to evaluate liver function levels (GOT, GPT, ALP, TP, Alb) and kidney function such as (Urea, Uric acid and Creatinine). Seventy individuals of Iraqi adults were divided into two groups: 50 thalassemic patients (28 male and 22 female) (group 1) and 20 normal individuals (10 male and 10 female) as control (healthy group) (group 2). The results show a significant increase (p ≤ 0.01) in (GOT, GPT and ALP) while also showed a significant decrease (p ≤ 0.01) in T.p and Alb levels of thalassemia patients compared with control group. The mean values of Uera, Uric acid and Creatinine in thalassemic patients were (42.75 ± 3.37, 9.27 ± 0.63 and 1.31 ± 0.13) mg/dl respectively as compared with control group (22.25 ± 1.41, 4.90 ± 0.23 and 0.623 ± 0.04) mg/dl respectively. Also, the results showed the effect of duration of disease on (GOT and Urea) level in thalassemic patients (p ≤ 0.05). Also, this study has no significant differences between male and female patients in all parameters study and also the effect of age on parameters was studied.
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