Journal américain de l'administration avancée de médicaments Libre accès

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A Method of Isolation of Capparisterol from Capparis decidua and Antinephrolithiasis Activity

Deepak Godara, Vichitra Kaushik, Gaurav Sharma and Vipin Saini

A kidney stone is similar to formation of calculi in kidney. It forms when chemicals in the body aggregate together. A stone may stay in the kidney or travel through the urinary system. Very small stones may pass through the urinary system without causing much pain. Larger stones can block the flow of urine if they get stuck in the ureters or urethra. The study was undertaken to investigate the anti nephrolithiasis activity of capparisterol. Capparisterol is administered by intra peritoneal route in 35 mg/kg and 70 mg/kg doses. In preventive regimen capparisterol 70 mg/kg (73.73% relief) show greater creatinine clearance then standard drug cystone 750 mg/kg and in curative regimen capparisterol 70 mg/kg (114.18% relief) has greater effect then cystone (97.45% relief). Test drug show dose dependent therapeutic efficacy. Therapeutic effect of test drug increase with increasing dose.